R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone

Base Information

Chemical Name:R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone
CAS No.:677277-65-5
Molecular Formula:C₁₃H₁₃BrF₃NO₄
Molecular Weight:384.15
Hs Code.:

Synonyms:R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone

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Technology Process of R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone

There total 2 articles about R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25245-34-5
1-bromo-2,5-dimethoxybenzene

: 677761-52-3
(R)-N-trifluoroacetylalanyl chloride

: 677277-65-5
R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 20 ℃; for 60h;
DOI:10.1021/jm040082s

Reference yield:

: 7592-26-9
(R)-2-(2,2,2-trifluoroacetamido)propanoic acid

: 677277-65-5
R-(+)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-propanone

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2; pyridine / CH₂Cl₂ / 2 h / 20 °C

2: 6.30 g / TiCl₄ / CH₂Cl₂ / 60 h / 20 °C

With pyridine; oxalyl dichloride; titanium tetrachloride; In dichloromethane; 2: Friedel-Crafts reaction;
DOI:10.1021/jm040082s