7-methyl-2-(4-methylphenyl)-1H-indole

Base Information

• Chemical Name: 7-methyl-2-(4-methylphenyl)-1H-indole
• CAS No.: 906782-97-6
• Molecular Formula: C₁₆H₁₅N
• Molecular Weight: 221.302
• Mol file: 906782-97-6.mol

Synonyms:7-methyl-2-(4-methylphenyl)-1H-indole

Chemical Property of 7-methyl-2-(4-methylphenyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 7-methyl-2-(4-methylphenyl)-1H-indole

There total 9 articles about 7-methyl-2-(4-methylphenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-methylphenyl)-2-(2-methylphenylamino)ethanone + o-toluidine (95-53-4) → 7-methyl-2-(4-methylphenyl)-1H-indole (906782-97-6)

Guidance literature:

1-(4-methylphenyl)-2-(2-methylphenylamino)ethanone; o-toluidine; With triphenylphosphine; palladium(II) bromide; In 2,2,2-trifluoroethanol; toluene; for 0.25h; Schlenk technique; Inert atmosphere;

With hydrogen; sodium sulfate; In 2,2,2-trifluoroethanol; toluene; at 150 ℃; for 24h; under 41372.9 Torr; regioselective reaction; Autoclave; Schlenk technique;

DOI:10.1002/ejoc.201900394

Reference yield: 82.0%

ortho-methylphenyl iodide (615-37-2) + (E)‐ 1‐(p‐tolyl)ethan‐1‐one O‐acetyl oxime (96475-75-1) → 7-methyl-2-(4-methylphenyl)-1H-indole (906782-97-6)

Guidance literature:

With trifuran-2-yl-phosphane; norbornene; palladium diacetate; potassium carbonate; In 1,4-dioxane; dimethyl sulfoxide; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.orglett.1c03679

Reference yield: 56.0%

C16H16ClN → 7-methyl-2-(4-methylphenyl)-1H-indole (906782-97-6)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 80 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.9b00600 DOI:10.1021/acs.orglett.9b00600

upstream raw materials:

2,6-dimethylformanilide

2,6-dimethylaniline

4-(bromoacetyl)toluene

o-toluidine