1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:851345-95-4
Molecular Formula:C₁₇H₂₀N₂O₆
Molecular Weight:348.356
Hs Code.:

Synonyms:1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 3 articles about 1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 851345-94-3
3'-O-tert-butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-C-phenoxymethylenethymidine

: 851345-95-4
1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/chem.200401114

Reference yield:

: trifluoro-methanesulfonic acid 3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 851345-95-4
1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1.5 h / -78 - 0 °C

1.2: 98.4 mg / dimethylformamide / 2.5 h / 0 - 50 °C

2.1: 93 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/chem.200401114

Reference yield:

: 162052-67-7
1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 851345-95-4
1-((2R,4S,5S)-4-Hydroxy-5-hydroxymethyl-5-phenoxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂ / 1.5 h / 0 °C

2.1: NaH / dimethylformamide / 1.5 h / -78 - 0 °C

2.2: 98.4 mg / dimethylformamide / 2.5 h / 0 - 50 °C

3.1: 93 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200401114