tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate

Base Information

Chemical Name:tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate
CAS No.:1613450-13-7
Molecular Formula:C₂₆H₄₂N₂O₆S
Molecular Weight:510.695
Hs Code.:

Synonyms:tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate

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Chemical Property of tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate

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Technology Process of tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate

There total 11 articles about tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₄₂N₂O₉S₂

: 1613450-13-7
tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate

Guidance literature:: With sodium dihydrogenphosphate; In water; ethyl acetate; acetonitrile; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2014.05.004

Reference yield:

: 1613450-04-6
tert-butyl 2-(benzylamino)-2-(hydroxymethyl)pentanoate

: 1613450-13-7
tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole; triethylamine; thionyl chloride / dichloromethane / 2.5 h / -10 - 20 °C / Inert atmosphere

2: rhodium(III) chloride hydrate; sodium periodate / water; acetonitrile / 4.25 h / 0 - 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C / Inert atmosphere

4: sodium dihydrogenphosphate / water; acetonitrile; ethyl acetate / 2 h / 50 °C / Inert atmosphere

With 1H-imidazole; sodium periodate; sodium dihydrogenphosphate; thionyl chloride; rhodium(III) chloride hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2014.05.004

Reference yield:

: 1613450-07-9
tert-butyl 3-benzyl-2-oxo-4-propyl-1,2,3-oxathiazolidine-4-carboxylate

: 1613450-13-7
tert-butyl 2-benzylamino-3-((R)-2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropylthio)-2-(1-propyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: rhodium(III) chloride hydrate; sodium periodate / water; acetonitrile / 4.25 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C / Inert atmosphere

3: sodium dihydrogenphosphate / water; acetonitrile; ethyl acetate / 2 h / 50 °C / Inert atmosphere

With sodium periodate; sodium dihydrogenphosphate; rhodium(III) chloride hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2014.05.004