6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine

Base Information

Chemical Name:6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine
CAS No.:1383625-14-6
Molecular Formula:C₁₈H₁₂FN₅O₂
Molecular Weight:349.324
Hs Code.:

Synonyms:6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine

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Chemical Property of 6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine

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Technology Process of 6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine

There total 5 articles about 6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1383625-13-5
2-chloro-6-(2-fluorophenyl)imidazo[1,2-b]pyridazine

: 1353715-51-1
2-methyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1383625-14-6
6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; isopropyl alcohol; at 80 ℃; for 12h; Inert atmosphere;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1383625-14-6
6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C

1.2: 0 - 40 °C

2.1: hydrogenchloride / water / 18 h / Reflux

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 100 °C / Microwave irradiation

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / isopropyl alcohol; water / 12 h / 80 °C / Inert atmosphere

With hydrogenchloride; potassium acetate; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 911434-05-4
5-bromo-2-methyl-3-nitropyridine

: 1383625-14-6
6-(2-fluorophenyl)-2-(6-methyl-5-nitropyridin-3-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 100 °C / Microwave irradiation

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / isopropyl alcohol; water / 12 h / 80 °C / Inert atmosphere

With potassium acetate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; isopropyl alcohol;