(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone

Base Information

Chemical Name:(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone
CAS No.:193960-65-5
Molecular Formula:C₃₃H₃₆N₂O₂S
Molecular Weight:524.727
Hs Code.:

Synonyms:(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone

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Chemical Property of (2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone

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Technology Process of (2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone

There total 6 articles about (2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 193964-19-1
2-[4-[2-(1-pyrrolidinyl)ethoxy]-phenyl]benzo[b]thiophene

: 4-(2-pyrrolidin-1-yl-ethyl)-benzoyl chloride

: 193960-65-5
(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone

Guidance literature:: With aluminium trichloride; In 1,2-dichloro-ethane; at 0 ℃; for 5h;
DOI:10.1021/jm9903388

Reference yield:

: 193964-24-8
methyl 4-[2-(1-pyrrolidinyl)ethyl]benzoate

: 193960-65-5
(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone

Guidance literature:: Multi-step reaction with 3 steps

1: 22 percent / H₂O; LiOH; HCl / tetrahydrofuran / 32 h / 20 - 50 °C

2: SOCl₂; DMF / 1,2-dichloro-ethane / 2 h / Heating

3: 45 percent / AlCl₃ / 1,2-dichloro-ethane / 5 h / 0 °C

With hydrogenchloride; lithium hydroxide; aluminium trichloride; thionyl chloride; water; N,N-dimethyl-formamide; In tetrahydrofuran; 1,2-dichloro-ethane; 1: Hydrolysis / 2: Chlorination / 3: Friedel-Crafts acylation;
DOI:10.1021/jm9903388

Reference yield:

: 4-[2-(1-pyrrolinyl)ethyl]benzoic acid hydrochloride

: 193960-65-5
(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl)-(4-[2-(1-pyrrolidinyl)ethyl]phenyl)ketone

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; DMF / 1,2-dichloro-ethane / 2 h / Heating

2: 45 percent / AlCl₃ / 1,2-dichloro-ethane / 5 h / 0 °C

With aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; 1: Chlorination / 2: Friedel-Crafts acylation;
DOI:10.1021/jm9903388