(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine

Base Information

• Chemical Name: (2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine
• CAS No.: 312639-10-4
• Molecular Formula: C₂₃H₃₂ClN₅O
• Molecular Weight: 429.993
• Mol file: 312639-10-4.mol

Synonyms:(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine

Chemical Property of (2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine

There total 10 articles about (2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc-D-(4-Cl)Phe-OH (57292-44-1) → (2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine (312639-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / 0.33 h / 0 °C

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/ml400115n

Reference yield:

9H-fluoren-9-ylmethyl {(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-2-oxoethyl}carbamate → (2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine (312639-10-4)

Guidance literature:

With piperidine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

(4-phenyl-piperidin-4-yl)-methanol (4220-08-0) → (2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxo-propan-2-amine (312639-10-4)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂; HCl / Rh/Al₂O₃ / methanol

2: Et₃N / methanol

3: Et₃N / CH₂Cl₂

4: dimethylformamide

5: HCl / CH₂Cl₂

6: EDC; HOBt; NMM / CH₂Cl₂

7: HCl / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; Rh/Al₂O₃; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm025539h

upstream raw materials:

[1-(4-chlorobenzyl)-2-(4-cyclohexyl-4-[1,2,4]triazole-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]carbamic acid tert-butyl ester

(4-phenyl-piperidin-4-yl)-methanol

Normeperidine

N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid