11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin

Base Information

• Chemical Name: 11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin
• CAS No.: 103681-51-2
• Molecular Formula: C₂₇H₂₆N₂O
• Molecular Weight: 394.516

Synonyms:11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin

Chemical Property of 11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin

Chemical Property:

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Technology Process of 11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin

There total 2 articles about 11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Dimethylamino-4,5-dihydro-1H-3-benzazepin (103681-63-6) + diphenylcyclopropenone (886-38-4) → 11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin (103681-51-2)

Guidance literature:

In diethyl ether; at 20 ℃; for 24h;

DOI:10.1055/s-1985-34144

Reference yield:

Homodihydrocarbostyril (15987-50-5) → 11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin (103681-51-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / 1.5 h / 160 °C

2: 80 percent / diethyl ether / 24 h / 20 °C

In diethyl ether;

DOI:10.1055/s-1985-34144

Reference yield: 75.0%

11a-Dimethylamino-1,2-diphenyl-3-oxo-5,6,11,11a-tetrahydro-3H-pyrrolo<1,2-b>-3-benzazepin (103681-51-2) → 1,2-Diphenyl-3-oxo-5,6-dihydro-3H-pyrrolo<1,2-b>-3-benzazepin

Guidance literature:

With methyl iodide; In acetonitrile; for 336h; Heating;

DOI:10.1055/s-1985-34144

upstream raw materials:

2-Dimethylamino-4,5-dihydro-1H-3-benzazepin

diphenylcyclopropenone

Homodihydrocarbostyril

Downstream raw materials:

6-Bromo-1,2-diphenyl-3-oxo-3H-pyrrolo<1,2-b>-3-benzazepin

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