[2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile

Base Information

Chemical Name:[2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile
CAS No.:877200-84-5
Molecular Formula:C₁₉H₂₁NO₂S
Molecular Weight:327.447
Hs Code.:

Synonyms:[2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile

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Chemical Property of [2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile

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Technology Process of [2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile

There total 1 articles about [2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 5804-85-3
diethylaluminium cyanide

: 794525-96-5
(S)-3-methyl-1-[2-(p-tolylsulfinyl)phenyl]butan-2-one

: 877200-84-5
[2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile

Guidance literature:: With ytterbium(III) triflate; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/j.tet.2005.10.067

Reference yield: 73.0%

: 877200-84-5
[2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile

: 877200-90-3
(2R)-2-hydroxy-3-methyl-2-[2-(p-tolylthio)benzyl]butanamide

Guidance literature:: [2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile; With tetrafluoroboric acid; In dichloromethane; at 40 ℃; for 6h;

With sodium iodide; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.tet.2005.10.067

Reference yield:

: 877200-84-5
[2R,(S)S]-2-hydroxy-3-methyl-2-[2-(p-tolylsulfinyl)benzyl]butanenitrile

: (R)-2-benzyl-2-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: fluoboric acid / CH₂Cl₂ / 6 h / 40 °C

1.2: 73 percent / NaI / CH₂Cl₂ / 15 h / 20 °C

2.1: 71 percent / Raney nickel / ethanol / 12 h / Heating

With tetrafluoroboric acid; nickel; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2005.10.067