2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide

Base Information

• Chemical Name: 2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide
• CAS No.: 256640-79-6
• Molecular Formula: C₁₇H₁₇ClN₂O₂
• Molecular Weight: 316.787
• Mol file: 256640-79-6.mol

Synonyms:2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide

Chemical Property of 2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide

There total 2 articles about 2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-methoxy-phenylamine (90-04-0) + 5,6-tetramethylene-2-chloroisonicotinic acid chloroanhydride → 2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide (256640-79-6)

Guidance literature:

With triethylamine; In benzene; at 50 ℃; for 1h;

DOI:10.1007/BF02508449

Reference yield:

2-chloro-5,6,7,8-tetrahydroquinoline-4-carboxylic acid (203509-54-0) → 2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide (256640-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / benzene / Heating

2: 59 percent / triethylamine / benzene / 1 h / 50 °C

With thionyl chloride; triethylamine; In benzene; 1: Chlorination / 2: Acylation;

DOI:10.1007/BF02508449

Reference yield:

aniline hydrochloride (142-04-1,36663-09-9) + 2-chloro-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide (256640-79-6) → 2-phenylamino-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid (2-methoxy-phenyl)-amide

Guidance literature:

In i-Amyl alcohol; for 20h; Heating;

DOI:10.1007/BF02508449

upstream raw materials:

2-methoxy-phenylamine

2-chloro-5,6,7,8-tetrahydroquinoline-4-carboxylic acid