benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate

Base Information

Chemical Name:benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate
CAS No.:1259536-39-4
Molecular Formula:C₃₄H₃₉N₃O₈S
Molecular Weight:649.765
Hs Code.:

Synonyms:benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate

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Chemical Property of benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate

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Technology Process of benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate

There total 11 articles about benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259536-25-8
N-(2-oxo-1-phenylpiperidin-3-yl)benzenesulfonamide

: 117997-81-6
5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid

: 1259536-39-4
benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate

Guidance literature:: N-(2-oxo-1-phenylpiperidin-3-yl)benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h; Inert atmosphere;

5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid; With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

Reference yield:

: 1259536-25-8
N-(2-oxo-1-phenylpiperidin-3-yl)benzenesulfonamide

: 13574-13-5
Boc-Glu(OBzl)-OH

: 1259536-39-4
benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate

Guidance literature:: N-(2-oxo-1-phenylpiperidin-3-yl)benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h; Inert atmosphere;

Boc-Glu(OBzl)-OH; With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 7.5h;

Reference yield:

: 62-53-3
aniline

: 1259536-39-4
benzyl 4-(tert-butoxycarbonylamino)-5-oxo-5-(N-(2-oxo-1-phenylpiperidin-3-yl)phenylsuIfonamido)pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.25 h / 0 °C

1.2: 0.83 h / 0 - 20 °C

2.1: ethanol; calcium chloride; sodium tetrahydroborate / 3.66 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

5.1: dichloromethane / 0.5 h / 20 °C / sealed tube

6.1: triethylamine / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 °C / Inert atmosphere

7.2: 6 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; calcium chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;