VAL-THR

Base Information

• Chemical Name: VAL-THR
• CAS No.: 72636-02-3
• Molecular Formula: C₉H₁₈N₂O₄
• Molecular Weight: 218.253
• Mol file: 72636-02-3.mol

Synonyms:L-Threonine,N-L-valyl-; 1670: PN: EP2071334 SEQID: 1761 claimed protein; 1670: PN:WO2009077864 SEQID: 1761 claimed protein; 473: PN: WO2005081628 SEQID: 1582claimed protein; 95: PN: US20070066537 PAGE: 17 claimed sequence

Chemical Property of VAL-THR

Chemical Property:

• PSA: 112.65000
• LogP: 0.01110
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

VAL-THR 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of VAL-THR

There total 5 articles about VAL-THR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-trifluoroacetyl-L-valyl-L-threonine methyl ester (1411764-26-5) → Val-Thr (72636-02-3)

Guidance literature:

N-trifluoroacetyl-L-valyl-L-threonine methyl ester; With sodium hydroxide; In ethanol; water;

With trifluoroacetic acid; pH=Ca. 6;

DOI:10.1134/S1070428012100065

Reference yield:

t-Boc-L-valine (13734-41-3) → Val-Thr (72636-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0.08 h / 0 - 5 °C

1.2: 40 h

2.1: sodium hydroxide / water

2.2: pH Ca_. 6

With dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1134/S1070428012100065

Reference yield:

methyl (tert-butoxycarbonyl)-L-valyl-L-threoninate (122751-44-4) → Val-Thr (72636-02-3)

Guidance literature:

methyl (tert-butoxycarbonyl)-L-valyl-L-threoninate; With sodium hydroxide; In water;

With hydrogenchloride; pH=Ca. 6;

DOI:10.1134/S1070428012100065

upstream raw materials:

t-Boc-L-valine

methyl (tert-butoxycarbonyl)-L-valyl-L-threoninate

N-trifluoroacetyl-L-valine

L-valine

Refernces