N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide

Base Information

Chemical Name:N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide
CAS No.:132451-19-5
Molecular Formula:C₂₃H₂₁N₃O₄S
Molecular Weight:435.503
Hs Code.:

Synonyms:N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide

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Chemical Property of N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide

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Technology Process of N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide

There total 11 articles about N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 132451-17-3
N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-ylidene)methyl>benzamide

: 132451-19-5
N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetic acid; for 2h; under 2585.7 Torr;
DOI:10.1021/jm00088a022

Reference yield:

: N-Methyl-N-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-4-[(thiazolidine-2,4-dion-5-ylidene)methyl]benzamide

: 132451-19-5
N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide

Guidance literature:: With acetic acid; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 70502-03-3
[5-methyl-2-phenyl-1,3-oxazol-4-yl]methanol

: 132451-19-5
N-methyl-N-<(5-methyl-2-phenyl-4-oxazolyl)methyl>-4<(2,4-dioxothiazolidin-5-yl)methyl>benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / pyridinium dichromate / CH₂Cl₂ / 7 h

2: MgSO₄ / diethyl ether / 1.) 0 deg C, 15 min, 2.) RT, 3 h

3: sodium borohydride / diethyl ether / 1.) 0 deg C, 15 min, 2.) RT, 18 h

4: tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) RT, overnight

5: 90 percent / sodium acetate / 2 h / 140 °C

6: 27 percent / H₂ / 10percent Pd/C / tetrahydrofuran; acetic acid / 2 h / 2585.7 Torr

With sodium tetrahydroborate; dipyridinium dichromate; hydrogen; sodium acetate; magnesium sulfate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid;
DOI:10.1021/jm00088a022