3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide

Base Information

Chemical Name:3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide
CAS No.:1380646-02-5
Molecular Formula:C₂₁H₂₀FN₃O₄S
Molecular Weight:429.472
Hs Code.:

Synonyms:3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide

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Chemical Property of 3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide

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Technology Process of 3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide

There total 7 articles about 3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1380646-54-7
acetic acid 5-[3-(3-fluorophenyl)-2-(4-methanesulfonylphenyl)-propionylamino]-pyrazin-2-ylmethyl ester

: 1380646-02-5
3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 5521-55-1
2-methylpyrazin-5-carboxylic acid

: 1380646-02-5
3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; diphenyl phosphoryl azide / 1,4-dioxane / 3 h / 100 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 4 h / 100 °C

3: 18-crown-6 ether; potassium acetate / acetonitrile / 72 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 20 °C

6: potassium carbonate / methanol / 0.5 h / 20 °C

With dmap; N-Bromosuccinimide; 18-crown-6 ether; 2,2'-azobis(isobutyronitrile); diphenyl phosphoryl azide; potassium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; acetonitrile;

Reference yield:

: 874476-54-7
acetic acid 5-tert-butoxycarbonylamino-pyrazin-2-yl-methyl ester

: 1380646-02-5
3-(3-Fluoro-phenyl)-N-(5-hydroxymethyl-pyrazin-2-yl)-2-(4-methanesulfonyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 20 °C

3: potassium carbonate / methanol / 0.5 h / 20 °C

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane;