N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide

Base Information

• Chemical Name: N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide
• CAS No.: 1027233-87-9
• Molecular Formula: C₂₁H₁₃F₃N₄O₃
• Molecular Weight: 426.354

Synonyms:N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide

Chemical Property of N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide

Chemical Property:

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Technology Process of N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide

There total 3 articles about N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide (1027233-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

With pyridine; PPA; In xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide (1027233-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

With pyridine; PPA; In xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-trifluoromethyl-phenyl acetyl chloride (329-15-7) + 5(6)-nitro 2-(4-aminophenyl)-1H-benzimidazole (71002-88-5) → N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide (1027233-87-9)

Guidance literature:

With pyridine; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2006.03.014

upstream raw materials:

4-trifluoromethyl-phenyl acetyl chloride

5⁽⁶⁾-nitro 2-(4-aminophenyl)-1H-benzimidazole

4-amino-benzoic acid

4-Nitrophenylene-1,2-diamine

Downstream raw materials:

N-[4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-4-trifluoromethyl-benzamide

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