tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

Base Information

Chemical Name:tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate
CAS No.:852714-69-3
Molecular Formula:C₄₃H₅₆N₆O₈
Molecular Weight:784.953
Hs Code.:

tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

Synonyms:tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

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Chemical Property of tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

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Technology Process of tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

There total 18 articles about tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852714-68-2
(2S,3S)-2-{[(tert-butyl)oxycarbonyl]methyl}-3-[4-nitrophenyl]pent-4-enoic acid

: 666259-67-2
N-{(2R)-2-[(5-methylindol-1-yl)methyl]pent-4-enyl}(2S)-2-[(aminocyclohexyl)carbonylamino]-3-carbamoylpropanamide

: 852714-69-3
tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 72h;
DOI:10.1021/jm050059m

Reference yield:

: 852714-67-1
tert-butyl 3-[((4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl)carbonyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

: 852714-69-3
tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 5 h / 20 °C

2: 408 mg / HOAt; EDCI*HCl / dimethylformamide / 72 h / 20 - 50 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm050059m

Reference yield:

: 852714-66-0
3-[(3R)-3-(4-nitrophenyl)pent-4-enoyl]-(4S)-4-phenyl-1,3-oxazolidin-2-one

: 852714-69-3
tert-butyl 3-[N-({N-1-(N-{(2R)-2-[(5-methylindolyl)methyl]pent-4-enyl}-(1S)-2-carbamoylethyl)carbamoyl}cyclohexyl)carbamoyl]-(3S,4S)-4-[4-nitrophenyl]hex-5-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

1.2: 56 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C

2.1: 95 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 5 h / 20 °C

3.1: 408 mg / HOAt; EDCI*HCl / dimethylformamide / 72 h / 20 - 50 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm050059m