(E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate

Base Information

• Chemical Name: (E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate
• CAS No.: 1263183-11-4
• Molecular Formula: C₃₆H₄₃NO₄
• Molecular Weight: 553.742
• Mol file: 1263183-11-4.mol

Synonyms:(E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate

Chemical Property of (E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate

There total 1 articles about (E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(E,1S,4aS,10aR)-methyl 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-9-(hydroxyimino)-1,4a-dimethylphenanthrene-1-carboxylate (1263183-09-0) + 1-Bromo-3-phenylpropane (637-59-2) → (E,1S,4aS,10aR)-methyl 6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-9-(hydroxyimino)-1,4a-dimethylphenanthrene-1-carboxylate (1263183-12-5) + (E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate (1263183-11-4)

Guidance literature:

(E,1S,4aS,10aR)-methyl 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-9-(hydroxyimino)-1,4a-dimethylphenanthrene-1-carboxylate; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-Bromo-3-phenylpropane; at 20 ℃;

DOI:10.1016/j.bmc.2010.09.072

Reference yield:

(E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate (1263183-11-4) → (E,1S,4aS,10aR)-10-hydroxy-9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylic acid (1263182-94-0)

Guidance literature:

(E,1S,4aS,10aR)-methyl 9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylate; With potassium tert-butylate; In dimethyl sulfoxide; at 60 ℃; for 2h;

With hydrogenchloride; In water; dimethyl sulfoxide; Cooling with ice;

DOI:10.1016/j.bmc.2010.09.072

upstream raw materials:

(E,1S,4aS,10aR)-methyl 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-9-(hydroxyimino)-1,4a-dimethylphenanthrene-1-carboxylate

1-Bromo-3-phenylpropane

Downstream raw materials:

(E,1S,4aS,10aR)-10-hydroxy-9-((3-phenylpropoxy)imino)-6-(3-phenylpropoxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthrene-1-carboxylic acid