(4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene

Base Information

Chemical Name:(4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene
CAS No.:199857-46-0
Molecular Formula:C₂₆H₄₆O₄Si
Molecular Weight:450.734
Hs Code.:

Synonyms:(4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene

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Chemical Property of (4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene

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Technology Process of (4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene

There total 10 articles about (4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-Methoxy-4-((3R,6R)-6-methyl-5-methylene-3-triethylsilanyloxy-7-triisopropylsilanyloxy-heptyloxymethyl)-benzene

: 199857-46-0
(4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; dichloromethane; at 20 ℃; for 0.166667h; Yield given;
DOI:10.1016/S0040-4039(97)10126-5

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 199857-46-0
(4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 99 percent / imidazole; DMAP / CH₂Cl₂ / 0 - 20 °C

2.1: 99.5 g / i-PrMgCl / tetrahydrofuran / 1 h / -20 °C

3.1: 75 percent / tetrahydrofuran; diethyl ether / 3 h / 0 °C

4.1: Et₃N / diethyl ether / -78 - 0 °C

5.1: diethyl ether / 21 h / -78 - -20 °C

5.2: 4.08 g / aq. H₂O₂ / methanol / 2.5 h / 20 °C

6.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -78 °C

7.1: Zn; PbI₂; TiCl₄ / tetrahydrofuran; CH₂Cl₂ / 4.5 h / 20 °C

8.1: 5.64 g / PPTS / methanol; CH₂Cl₂ / 0.5 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; dmap; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; titanium tetrachloride; triethylamine; lead(II) iodide; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1039/b504146e

Reference yield:

: 158783-84-7
(S)-methyl 2-methyl-3-(triisopropylsilyloxy)propanoate

: 199857-46-0
(4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99.5 g / i-PrMgCl / tetrahydrofuran / 1 h / -20 °C

2.1: 75 percent / tetrahydrofuran; diethyl ether / 3 h / 0 °C

3.1: Et₃N / diethyl ether / -78 - 0 °C

4.1: diethyl ether / 21 h / -78 - -20 °C

4.2: 4.08 g / aq. H₂O₂ / methanol / 2.5 h / 20 °C

5.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -78 °C

6.1: Zn; PbI₂; TiCl₄ / tetrahydrofuran; CH₂Cl₂ / 4.5 h / 20 °C

7.1: 5.64 g / PPTS / methanol; CH₂Cl₂ / 0.5 h / 20 °C

With 2,6-dimethylpyridine; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; titanium tetrachloride; triethylamine; lead(II) iodide; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1039/b504146e