3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester

Base Information

• Chemical Name: 3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester
• CAS No.: 1631153-92-8
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.214
• Mol file: 1631153-92-8.mol

Synonyms:3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester

Chemical Property of 3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester

There total 2 articles about 3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxo-3-p-tolyl-propionic acid methyl ester (22027-51-6) → 3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester (1631153-92-8) + C11H10O4 (229633-45-8)

Guidance literature:

3-oxo-3-p-tolyl-propionic acid methyl ester; With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In acetonitrile; at 20 ℃; for 0.0833333h;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In acetonitrile; at 20 ℃; for 12h; Overall yield = 90 %;

DOI:10.1016/j.tet.2014.04.021

Reference yield:

3-oxo-3-p-tolyl-propionic acid methyl ester (22027-51-6) → 3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester (1631153-92-8)

Guidance literature:

With water; bis-[(trifluoroacetoxy)iodo]benzene; at 20 ℃; for 0.166667h;

DOI:10.1039/c4cc06395c

Reference yield:

3-(4-tolyl)-2-hydroxy-3-oxopropionic acid methyl ester (1631153-92-8) → C11H13NO6S

Guidance literature:

With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c4cc06395c

upstream raw materials:

3-oxo-3-p-tolyl-propionic acid methyl ester