(S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile

Base Information

• Chemical Name: (S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile
• CAS No.: 194095-24-4
• Molecular Formula: C₂₀H₂₂N₂
• Molecular Weight: 290.408
• Mol file: 194095-24-4.mol

Synonyms:(S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile

Chemical Property of (S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile

There total 2 articles about (S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-methylphenylacetic acid (621-36-3) → (S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile (194095-24-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / toluene / 80 - 85 °C

2: 1.) AlCl₃ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, from -40 to -30 deg C

3: 1.) aq. AcOH / 1.) MeOH, EtOH, 35 deg C, 2.) MeOH, EtOH, a) 40 deg C, 3.5 h, b) RT, 24 h

With aluminium trichloride; thionyl chloride; acetic acid; In toluene;

DOI:10.1021/jm970282m

Reference yield:

7-methyl-2-tetralone (31706-56-6) + (R)-1-phenyl-ethyl-amine (3886-69-9) + sodium cyanide (143-33-9,25596-52-5) → (S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile (194095-24-4)

Guidance literature:

With acetic acid; Yield given. Multistep reaction; 1.) MeOH, EtOH, 35 deg C, 2.) MeOH, EtOH, a) 40 deg C, 3.5 h, b) RT, 24 h;

DOI:10.1021/jm970282m

Reference yield:

(S)-7-Methyl-2-((R)-1-phenyl-ethylamino)-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile (194095-24-4) → ((S)-2-Aminomethyl-7-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-((R)-1-phenyl-ethyl)-amine

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm970282m

upstream raw materials:

7-methyl-2-tetralone

(R)-1-phenyl-ethyl-amine

sodium cyanide

m-methylphenylacetic acid