α-(o-acetamidophenyl)neopentyl alcohol

Base Information

• Chemical Name: α-(o-acetamidophenyl)neopentyl alcohol
• CAS No.: 100702-92-9
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 100702-92-9.mol

Synonyms:α-(o-acetamidophenyl)neopentyl alcohol

Chemical Property of α-(o-acetamidophenyl)neopentyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of α-(o-acetamidophenyl)neopentyl alcohol

There total 1 articles about α-(o-acetamidophenyl)neopentyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-oxo-3,1-benzoxazine (525-76-8) + tertiary butyl chloride (507-20-0) → α-(o-acetamidophenyl)neopentyl alcohol (100702-92-9)

Guidance literature:

With hydrogenchloride; magnesium; Yield given. Multistep reaction; 1.) ether, benzene, 3 h, 2.) ether, benzene;

DOI:10.1021/jo00358a005

Reference yield: 92.0%

α-(o-acetamidophenyl)neopentyl alcohol (100702-92-9) → α-(o-aminophenyl)neopentyl alcohol (100702-93-0)

Guidance literature:

With potassium hydroxide; In methanol; water; for 23h; Heating;

DOI:10.1021/jo00358a005

Reference yield:

α-(o-acetamidophenyl)neopentyl alcohol (100702-92-9) → α-neopenyl chloride (100702-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / KOH / methanol; H₂O / 23 h / Heating

2: 77 percent / thionyl chloride / benzene / 23 h / Heating

With potassium hydroxide; thionyl chloride; In methanol; water; benzene;

DOI:10.1021/jo00358a005

upstream raw materials:

2-methyl-4-oxo-3,1-benzoxazine

tertiary butyl chloride

Downstream raw materials:

α-(o-aminophenyl)neopentyl alcohol

α-neopenyl chloride

α-(o-aminophenyl)neopentyl chloride hydrochloride

(R)-(+)-α-phenylneopenyl chloride