N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide
CAS No.:1448991-13-6
Molecular Formula:C₂₅H₂₈N₂O₂S
Molecular Weight:420.576
Hs Code.:

Synonyms:N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide

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Chemical Property of N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide

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Technology Process of N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide

There total 4 articles about N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1448991-03-4
(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methanamine

: 98-59-9
p-toluenesulfonyl chloride

: 1448991-13-6
N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.3987/COM-12-S(N)82

Reference yield:

: 110529-27-6
(S)-1-[(2S)-1-benzylpyrrolidin-2-yl](phenyl)methanol

: 1448991-13-6
N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonyl chloride; triethylamine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: sodium azide / dimethyl sulfoxide; N,N-dimethyl-formamide / 2 h / 55 °C / Microwave irradiation

3: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 3102.97 Torr

4: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-S(N)82

Reference yield:

: 1448990-99-5
(2R,3R)-1-benzyl-3-chloro-2-phenylpiperidine

: 1448991-13-6
N-{(S)-[(S)-1-benzylpyrrolidin-2-yl](phenyl)methyl}-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / dimethyl sulfoxide; N,N-dimethyl-formamide / 2 h / 55 °C / Microwave irradiation

2: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 3102.97 Torr

3: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-S(N)82