C₁₅H₁₄BrNO₅

Base Information

• Chemical Name: C₁₅H₁₄BrNO₅
• CAS No.: 1395315-82-8
• Molecular Formula: C₁₅H₁₄BrNO₅
• Molecular Weight: 368.184
• Mol file: 1395315-82-8.mol

Synonyms:C₁₅H₁₄BrNO₅

Chemical Property of C₁₅H₁₄BrNO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₄BrNO₅

There total 4 articles about C₁₅H₁₄BrNO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C19H22BrNO7 (1395316-35-4) → C15H14BrNO5 (1395315-82-8)

Guidance literature:

With chlorotriisopropylsilane; trifluoroacetic acid; In water; at 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2012.06.032

Reference yield:

3-carboxyphenylboronic acid pinacol ester (269409-73-6) → C15H14BrNO5 (1395315-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation; Autoclave

3: chlorotriisopropylsilane; trifluoroacetic acid / water / 1.5 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; chlorotriisopropylsilane; tetrabutylammomium bromide; benzotriazol-1-ol; triethylamine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Suzuki coupling;

DOI:10.1016/j.bmc.2012.06.032

Reference yield:

morpholin-4-yl-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxa-borolan-2-yl)-phenyl]-methanone (1036991-25-9) → C15H14BrNO5 (1395315-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation; Autoclave

2: chlorotriisopropylsilane; trifluoroacetic acid / water / 1.5 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; chlorotriisopropylsilane; tetrabutylammomium bromide; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; water; 1: Suzuki coupling;

DOI:10.1016/j.bmc.2012.06.032

upstream raw materials:

3-carboxyphenylboronic acid pinacol ester

morpholin-4-yl-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxa-borolan-2-yl)-phenyl]-methanone

C₁₉H₂₂BrNO₇

3-Carboxyphenylboronic acid