1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole

Base Information

Chemical Name:1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole
CAS No.:1303951-61-2
Molecular Formula:C₃₀H₂₄ClIN₂O₂S
Molecular Weight:638.956
Hs Code.:

Synonyms:1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole

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Chemical Property of 1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole

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Technology Process of 1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole

There total 3 articles about 1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1303951-51-0
3-[3-(4-chlorophenyl)-2-propynyl-(4-methylphenyl)sulfonamido]-9-ethyl-9H-carbazole

: 1303951-61-2
1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole

Guidance literature:: With iodine; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 4h; regioselective reaction;
DOI:10.1055/s-0030-1259530

Reference yield:

: 256385-64-5
9-ethyl-3-(4-methylphenylsulfonamido)-9H-carbazole

: 1303951-61-2
1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C

1.2: 10 h / Reflux

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

3.1: iodine; sodium hydrogencarbonate / acetonitrile / 4 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium hydrogencarbonate; potassium carbonate; triethylamine; In tetrahydrofuran; acetonitrile; 2.1: Sonogashira coupling;
DOI:10.1055/s-0030-1259530

Reference yield:

: 1303951-68-9
9-ethyl-3-[(2-propynyl)-4-methylphenylsulfonamido]-9H-carbazole

: 1303951-61-2
1-(4-chlorophenyl)-7-ethyl-2-iodo-4-(4-methylphenylsulfonyl)-4,7-dihydro-3H-pyrido[2,3-c]carbazole

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

2: iodine; sodium hydrogencarbonate / acetonitrile / 4 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; acetonitrile; 1: Sonogashira coupling;
DOI:10.1055/s-0030-1259530