(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile

Base Information

Chemical Name:(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile
CAS No.:838856-28-3
Molecular Formula:C₁₄H₁₉F₂NOSi
Molecular Weight:283.393
Hs Code.:

Synonyms:(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile

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Chemical Property of (3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile

Chemical Property:

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Technology Process of (3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile

There total 3 articles about (3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 838856-27-2
{[3-(bromomethyl)-2,5-difluorophenyl]oxy}(1,1-dimethylethyl)dimethylsilane

: 151-50-8
potassium cyanide

: 838856-28-3
(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

: 179421-00-2
3-tert-butyldimethylsilyloxy-2,5-difluorobenzaldehyde

: 838856-28-3
(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; ethanol / 0.5 h / 0 - 20 °C

2: phosphorus tribromide / toluene / 15 h / 20 °C

3: dimethyl sulfoxide / 1 h / 20 °C

With sodium tetrahydroborate; ethanol; phosphorus tribromide; In dimethyl sulfoxide; toluene;

Reference yield:

: 2713-31-7
2,5-difluorophenol

: 838856-28-3
(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2,5-difluorophenyl)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 15 h / 20 °C

2.1: sec.-butyllithium / tetrahydrofuran / 1 h / -70 °C

2.2: 0.5 h / -70 °C

3.1: sodium tetrahydroborate; ethanol / 0.5 h / 0 - 20 °C

4.1: phosphorus tribromide / toluene / 15 h / 20 °C

5.1: dimethyl sulfoxide / 1 h / 20 °C

With sodium tetrahydroborate; ethanol; sec.-butyllithium; phosphorus tribromide; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;