1,3,2-Dioxathiolane, 4-methyl-, 2,2- dioxide, (4S)-

Base Information

• Chemical Name: 1,3,2-Dioxathiolane, 4-methyl-, 2,2- dioxide, (4S)-
• CAS No.: 174953-30-1
• Molecular Formula: C₃H₆O₄S
• Molecular Weight: 138.144
• Hs Code.: 2934999090
• Mol file: 174953-30-1.mol

Synonyms:(S)-(+)-4-methyl-2,2-dioxo-1,3,2-dioxathiolane

Chemical Property of 1,3,2-Dioxathiolane, 4-methyl-, 2,2- dioxide, (4S)-

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(4S)-Methyl-[1,3,2]dioxathiolane2,2-dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,2-Dioxathiolane, 4-methyl-, 2,2- dioxide, (4S)-

There total 3 articles about 1,3,2-Dioxathiolane, 4-methyl-, 2,2- dioxide, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-1,2-Propanediol (4254-15-3,63625-56-9) → (S)-(+)-4-methyl-2,2-dioxo-1,3,2-dioxathiolane (174953-30-1)

Guidance literature:

(S)-1,2-Propanediol; With thionyl chloride; In dichloromethane; at 20 ℃; Reflux; Inert atmosphere;

With sodium periodate; ruthenium (III) chloride trihydrate; In dichloromethane; water; acetonitrile; at 0 - 20 ℃;

DOI:10.1021/ol1016492

Reference yield:

(S)-4-methyl-[1,3,2]dioxathiolane 2-oxide (221370-80-5) → (S)-(+)-4-methyl-2,2-dioxo-1,3,2-dioxathiolane (174953-30-1)

Guidance literature:

With ruthenium trichloride; sodium periodate; Yield given;

DOI:10.1016/S0957-4166(98)00245-6

Reference yield:

(S)-Propylene oxide (16088-62-3) → (S)-(+)-4-methyl-2,2-dioxo-1,3,2-dioxathiolane (174953-30-1)

Guidance literature:

(S)-Propylene oxide; With thionyl chloride; In tetrachloromethane; dichloromethane; for 0.5h; Heating;

With ruthenium trichloride; sodium periodate; acetonitrile; In tetrachloromethane; dichloromethane; water; at 20 ℃; for 0.5h;

DOI:10.1081/SCC-120015819

upstream raw materials:

(S)-1,2-Propanediol

(S)-4-methyl-[1,3,2]dioxathiolane 2-oxide

(S)-Propylene oxide

Downstream raw materials:

(S)-1-(1-phenylsulfonylindol-2-yl)propan-2-ol

(R)-(isopropyl)2PCH₂CH(Me)P(phenyl)2

(R)-(tert-butyl)2PCH₂CH(Me)P(phenyl)2

(R)-(cyclohexyl)2PCH₂CH(Me)P(phenyl)2

Refernces

• 1、 Bates, Roderick W.,Lu, Yongna. "Synthesis of (-)-sedinine by allene cyclization and iminium Ion chemistry". supporting information; experimental part. p. 3938 - 3941. Retrieved 2010/11/04.
• 2、 Nakaya, Mino,Oguri, Hiroki,Takahashi, Kosaku,Fukushi, Eri,Watanabe, Kenji,Oikawa, Hideaki. "Relative and absolute configuration of antitumor agent SW-163D". . p. 2969 - 2976. Retrieved 2008/03/14.