5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine
CAS No.:1383579-61-0
Molecular Formula:C₁₄H₁₂Cl₂N₄OS
Molecular Weight:355.247
Hs Code.:

Synonyms:5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine

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Chemical Property of 5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine

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Technology Process of 5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine

There total 4 articles about 5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1383579-51-8
N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-N-(2,5-dichlorophenyl)-4-nitrobenzenesulfonamide

: 1383579-61-0
5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine

Guidance literature:: With lithium hydroxide monohydrate; mercaptoacetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0031-1290524

Reference yield:

: 95-82-9
2,5 dichloroaniline

: 1383579-61-0
5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With pyridine; lithium hydroxide monohydrate; mercaptoacetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524

Reference yield:

: 1198054-16-8
ethyl 4-amino-2-(methylthio)furo[2,3-d]pyrimidine-5-carboxylate

: 1383579-61-0
5-[(2,5-dichlorophenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -50 - 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; lithium hydroxide monohydrate; mercaptoacetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524