(2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan

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Chemical Name:(2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan
CAS No.:214405-72-8
Molecular Formula:C₃₀H₅₀O₆
Molecular Weight:506.723
Hs Code.:

Synonyms:(2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan

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Chemical Property of (2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan

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Technology Process of (2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan

There total 5 articles about (2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 107-30-2
chloromethyl methyl ether

: 214405-71-7
(9E)-(11S,12R,15R,16R)-19-benzyloxy-11-(methoxymethoxy)-12,15-oxido-9-nonadecen-16-ol

: 214405-72-8
(2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jo981103r

Reference yield:

: 204572-66-7
(4R,5R)-8-Benzyloxy-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-octanal

: 214405-72-8
(2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.5 h / -78 °C

2: 96 percent / pyridine / 12 h

3: 88 percent / TBAF / tetrahydrofuran / 12 h / 50 °C

4: 92 percent / diisopropylethylamine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Addition / 2: Tosylation / 3: Cyclization / 4: Etherification;
DOI:10.1021/jo981103r

Reference yield:

: Tributyl-[(R)-1-((Z)-2-methoxymethoxy-vinyl)-nonyl]-stannane

: 214405-72-8
(2R,5R)-2-((R)-4-Benzyloxy-1-methoxymethoxy-butyl)-5-((E)-(S)-1-methoxymethoxy-undec-2-enyl)-tetrahydro-furan

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.5 h / -78 °C

2: 96 percent / pyridine / 12 h

3: 88 percent / TBAF / tetrahydrofuran / 12 h / 50 °C

4: 92 percent / diisopropylethylamine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Addition / 2: Tosylation / 3: Cyclization / 4: Etherification;
DOI:10.1021/jo981103r