(3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol

Base Information

Chemical Name:(3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol
CAS No.:1528746-82-8
Molecular Formula:C₃₉H₅₄O₆Si
Molecular Weight:646.94
Hs Code.:

Synonyms:(3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol

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Chemical Property of (3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol

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Technology Process of (3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol

There total 7 articles about (3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1528746-81-7
(4R,2E)-4-{2-[(3R)-1-(tert-butyldiphenylsilyloxy)-4-hydroxy-4-methylpentan-3-yloxy]-5-(methoxymethoxy)-4-methylphenyl}pent-2-en-1-ol

: 106-95-6
allyl bromide

: 1528746-82-8
(3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol

Guidance literature:: (4R,2E)-4-{2-[(3R)-1-(tert-butyldiphenylsilyloxy)-4-hydroxy-4-methylpentan-3-yloxy]-5-(methoxymethoxy)-4-methylphenyl}pent-2-en-1-ol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.tet.2013.11.070

Reference yield:

: 1313708-38-1
(2R,3E)-2-[5-(benzyloxy)pent-3-en-2-yl]-4-(methoxymethoxy)-5-methylphenol

: 1528746-82-8
(3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.1: lithium di-tert-buthylbiphenilide / tetrahydrofuran / 0.05 h / -78 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 6 h / 0 - 20 °C / Inert atmosphere

With lithium di-tert-buthylbiphenilide; sodium hydride; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.tet.2013.11.070

Reference yield:

: 1528746-69-1
(2S)-methyl 2-(trifluoromethylsulfonyloxy)-4-(tert-butyldiphenylsilyloxy)butanoate

: 1528746-82-8
(3R)-3-{2-[(2R,3E)-5-(allyloxy)pent-3-en-2-yl-4-(methoxymethoxy)-5-methylphenoxy]-5-tert-butyldiphenylsilyloxy}-2-methylpentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 4 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.1: lithium di-tert-buthylbiphenilide / tetrahydrofuran / 0.05 h / -78 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 6 h / 0 - 20 °C / Inert atmosphere

With lithium di-tert-buthylbiphenilide; sodium hydride; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.tet.2013.11.070