(2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

Base Information

Chemical Name:(2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol
CAS No.:99285-00-4
Molecular Formula:C₃₆H₅₆O₇Si
Molecular Weight:628.922
Hs Code.:

(2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

Synonyms:(2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

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Chemical Property of (2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

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Technology Process of (2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

There total 7 articles about (2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 99284-99-8
(2R,3R,5R,6R,8S,9R,10S,11S)-8-Ethyl-2-((S)-2-hydroxy-1-methyl-ethyl)-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 99285-00-4
(2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 1h;
DOI:10.1139/v85-468

Reference yield:

: 99300-05-7,107437-45-6,107437-46-7
(3S,5R,6S,8S,9R,10S,11S)-8-Ethyl-9,10-dihydroxy-5,9,11-trimethyl-3-phenylselanyl-1,7-dioxa-spiro[5.5]undecane-3-carboxylic acid methyl ester

: 99285-00-4
(2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

Guidance literature:: Multi-step reaction with 7 steps

1: H₂O₂ / pyridine; CH₂Cl₂ / 25 deg C, 30 min, 45 deg C, 30 min

2: 90 percent / LAH / tetrahydrofuran / 2 h / 0 - 25 °C

3: 99 percent / triethylamine, DMAP / 1 h / 25 °C

4: 90 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / 50 °C

6: 90 percent / LAH / tetrahydrofuran / 0 deg C, 5 min, 25 deg C, 1 h

7: 95 percent / imidazole / dimethylformamide / 1 h / 25 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; dihydrogen peroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v85-468

Reference yield:

: (2S,3R,4S,5S,6S,11R)-2-Ethyl-3,5,11-trimethyl-1,7-dioxa-spiro[5.5]undec-8-ene-3,4,9-triol

: 99285-00-4
(2R,3R,5R,6R,8S,9R,10S,11S)-2-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-8-ethyl-9-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undecane-3,10-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / triethylamine, DMAP / 1 h / 25 °C

2: 90 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / 50 °C

4: 90 percent / LAH / tetrahydrofuran / 0 deg C, 5 min, 25 deg C, 1 h

5: 95 percent / imidazole / dimethylformamide / 1 h / 25 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v85-468