(1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester

Base Information

• Chemical Name: (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester
• CAS No.: 637767-38-5
• Molecular Formula: C₃₆H₄₁N₃O₇
• Molecular Weight: 627.737

Synonyms:(1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester

Chemical Property of (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester

Chemical Property:

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Technology Process of (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester

There total 5 articles about (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Pent-4-enoic acid ((S)-2-hydroxy-propyl)-amide + (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid (637767-44-3) → (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester (637767-38-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1021/ol035773h

Reference yield:

(1S,2S,5R,6R,7R)-2-Benzylcarbamoyl-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid ethyl ester → (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester (637767-38-5)

Guidance literature:

Multi-step reaction with 5 steps

1: CsOH*H₂O / tetrahydrofuran / 8 h / 20 °C

2: Ba(OH)2*8H₂O / tetrahydrofuran / 12 h / 20 °C

3: 45 percent / EDC*HCl; DMAP / CH₂Cl₂ / 20 °C

4: 93 percent / Ba(OH)2*8H₂O / methanol / 12 h / 20 °C

5: 60 percent / EDC*HCl; DMAP / CH₂Cl₂ / 20 °C

With dmap; barium dihydroxide; cesium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ol035773h

Reference yield:

(1S,2S,5R,6R,7R)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid → (1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.01,5]dec-8-ene-6-carboxylic acid (S)-1-methyl-2-pent-4-enoylamino-ethyl ester (637767-38-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / EDC*HCl; DMAP / CH₂Cl₂ / 20 °C

2: 93 percent / Ba(OH)2*8H₂O / methanol / 12 h / 20 °C

3: 60 percent / EDC*HCl; DMAP / CH₂Cl₂ / 20 °C

With dmap; barium dihydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

DOI:10.1021/ol035773h

upstream raw materials:

(1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid

(1R,2R,5S,6S,7S)-2-(Allyl-benzyl-carbamoyl)-3-(4-methoxy-benzyl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0^1,5]dec-8-ene-6-carboxylic acid (1R,2R)-2-(methyl-pent-4-enoyl-amino)-1-phenyl-propyl ester

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