1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide

Base Information

• Chemical Name: 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide
• CAS No.: 417715-52-7
• Molecular Formula: C₂₀H₂₃BrN₃O₃P
• Molecular Weight: 464.299

Synonyms:1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide

Chemical Property of 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide

Chemical Property:

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Technology Process of 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide

There total 5 articles about 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ⁵-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

p-Tolylisocyanate (622-58-2,374675-64-6) + 1-(2-bromoethyl)-3-propyl-2,3-dihydro-1,2,3-benzodiazaphosphorin-4(1H)-one 2-oxide (404958-71-0) → 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ5-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide (417715-52-7)

Guidance literature:

In tetrahydrofuran; triethylamine; at 20 ℃; for 3h;

DOI:10.1002/hc.1107

Reference yield:

isatoic anhydride (118-48-9) → 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ5-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide (417715-52-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 96.5 percent / dioxane / 1.5 h / 60 - 70 °C

2: 62.8 percent / sodium bicarbonate / acetonitrile / 8 h / Heating

3: 63.8 percent / phosphorus trichloride / benzene / 5 h / Heating

4: 93.8 percent / triethylamine; tetrahydrofuran / 3 h / 20 °C

With sodium hydrogencarbonate; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; triethylamine; acetonitrile; benzene;

DOI:10.1002/hc.1107

Reference yield:

2-amino-N-propylbenzamide (56814-10-9) → 1-(2-bromo-ethyl)-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-2λ5-benzo[1,3,2]diazaphosphinine-2-carboxylic acid p-tolylamide (417715-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 62.8 percent / sodium bicarbonate / acetonitrile / 8 h / Heating

2: 63.8 percent / phosphorus trichloride / benzene / 5 h / Heating

3: 93.8 percent / triethylamine; tetrahydrofuran / 3 h / 20 °C

With sodium hydrogencarbonate; phosphorus trichloride; In tetrahydrofuran; triethylamine; acetonitrile; benzene;

DOI:10.1002/hc.1107

upstream raw materials:

p-Tolylisocyanate

1-(2-bromoethyl)-3-propyl-2,3-dihydro-1,2,3-benzodiazaphosphorin-4(1H)-one 2-oxide

isatoic anhydride

2-amino-N-propylbenzamide

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