Technology Process of 9-[(2R,3S,4S)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine
There total 10 articles about 9-[(2R,3S,4S)-2,3-bis(tert-butyldiphenylsilanyloxymethyl)thietan-4-yl]adenine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 48h;
DOI:10.1021/jm050912h
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: NaOMe / methanol / 16 h
1.2: NaBH4 / methanol / 2 h
2.1: 92 percent / imidazole / CH2Cl2 / 3 h / 20 °C
3.1: mCPBA / CH2Cl2 / 0.5 h / -78 °C
4.1: hexamethyldisilazane / acetonitrile / 3 h / Heating
4.2: Et3N; TMSOTf; ZnI2 / toluene / 24 h / 0 °C
5.1: NaN3 / dimethylformamide / 16 h / 20 °C
6.1: H2 / Pd/C / methanol / 48 h
With
1H-imidazole; sodium azide; hydrogen; sodium methylate; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm050912h
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: BH3*SMe2 / tetrahydrofuran / 2.5 h / 0 - 20 °C
1.2: 64 percent / aq. H2O2; NaOH / tetrahydrofuran / 2 h
2.1: oxalyl chloride; DMSO; Et3N / CH2Cl2 / -78 - 20 °C
3.1: NaOMe / methanol / 16 h
3.2: NaBH4 / methanol / 2 h
4.1: 92 percent / imidazole / CH2Cl2 / 3 h / 20 °C
5.1: mCPBA / CH2Cl2 / 0.5 h / -78 °C
6.1: hexamethyldisilazane / acetonitrile / 3 h / Heating
6.2: Et3N; TMSOTf; ZnI2 / toluene / 24 h / 0 °C
7.1: NaN3 / dimethylformamide / 16 h / 20 °C
8.1: H2 / Pd/C / methanol / 48 h
With
1H-imidazole; sodium azide; oxalyl dichloride; dimethylsulfide borane complex; hydrogen; sodium methylate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
2.1: Swern oxidation;
DOI:10.1021/jm050912h
![6-azido-9-[3,4-bis-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-thietan-2-yl]-9<i>H</i>-purine](/Databaselist/images/loading.webp)
