Technology Process of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-methylphenyl)acrylic acid
There total 6 articles about (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-methylphenyl)acrylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; potassium hydroxide;
In
methanol;
at 85 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bromine / chloroform / 0.5 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere
2.2: 3.33 h / -78 - 20 °C / Inert atmosphere
2.3: 2 h
3.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / water / 0.33 h / 20 - 150 °C / Inert atmosphere
4.1: potassium hydroxide; water / methanol / 1 h / 85 °C
With
n-butyllithium; tetrabutylammomium bromide; water; bromine; palladium diacetate; sodium carbonate; potassium hydroxide;
In
tetrahydrofuran; methanol; hexane; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.5 h / -30 °C
1.2: 1.5 h / -30 °C
2.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / water / 0.33 h / 20 - 150 °C / Inert atmosphere
3.1: potassium hydroxide; water / methanol / 1 h / 85 °C
With
tetrabutylammomium bromide; water; palladium diacetate; sodium hydride; sodium carbonate; potassium hydroxide;
In
methanol; 1,2-dimethoxyethane; water; mineral oil;
