Technology Process of C22H12ClF5O3
There total 5 articles about C22H12ClF5O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C15H10ClIO3;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at -30 ℃;
for 2h;
Inert atmosphere;
With
zinc dibromide;
In
tetrahydrofuran;
at -30 - 20 ℃;
for 0.666667h;
Inert atmosphere;
1-bromo-3,5-difluoro-4-trifluoromethylbenzene;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 70 ℃;
for 12h;
Inert atmosphere;
DOI:10.1002/chem.201102802
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -50 °C / Inert atmosphere
1.2: 0.67 h / -50 - 20 °C / Inert atmosphere
1.3: 12 h / 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
3.1: boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 0 - 70 °C
4.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere
4.2: 0.67 h / -30 - 20 °C / Inert atmosphere
4.3: 12 h / 70 °C / Inert atmosphere
With
boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; isopropylmagnesium chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.3: Negishi cross-coupling reaction / 4.3: Negishi cross-coupling reaction;
DOI:10.1002/chem.201102802
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
2.1: boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 0 - 70 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -30 °C / Inert atmosphere
3.2: 0.67 h / -30 - 20 °C / Inert atmosphere
3.3: 12 h / 70 °C / Inert atmosphere
With
boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; isopropylmagnesium chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
3.3: Negishi cross-coupling reaction;
DOI:10.1002/chem.201102802
