3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

Base Information

Chemical Name:3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole
CAS No.:84231-35-6
Molecular Formula:C₂₈H₂₇ClF₂N₂O
Molecular Weight:480.985
Hs Code.:

Synonyms:3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

Suppliers and Price of 3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

There total 3 articles about 3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84163-18-8
4-(6-chloro-benzo[d]isoxazol-3-yl)piperidiniuim chloride

: 3312-04-7
4-chloro-1,1-bis(4-fluorophenyl)butane

: 84231-35-6
3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

Guidance literature:: With sodium hydrogencarbonate; potassium iodide; In N,N-dimethyl-formamide; at 75 ℃; for 5h;
DOI:10.1021/jm00383a012

Reference yield:

: 84163-11-1
3-(1-formyl-4-piperidyl)-6-chloro-1,2-benzisoxazole

: 84231-35-6
3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / aq. HCl / ethanol / 3 h / Heating

2: NaHCO₃, KI / dimethylformamide / 5 h / 75 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00383a012

Reference yield:

: 84162-98-1
1-Formyl-4-(2,4-dichlorobenzoyl)piperidine oxime

: 84231-35-6
3-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-6-chloro-benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / NaH / dimethylformamide / 4 h / 70 - 75 °C

2: 74 percent / aq. HCl / ethanol / 3 h / Heating

3: NaHCO₃, KI / dimethylformamide / 5 h / 75 °C

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; potassium iodide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00383a012