Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide
• CAS No.: 261363-01-3
• Molecular Formula: C₁₄H₁₃N₅O₄
• Molecular Weight: 315.288
• Mol file: 261363-01-3.mol

Synonyms:Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide

Chemical Property of Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide

There total 1 articles about Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

isoniazid (54-85-3,7640-37-1) + 2-(4-nitrophenoxy)acetonitrile (33901-46-1) → Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide (261363-01-3)

Guidance literature:

2-(4-nitrophenoxy)acetonitrile; With sodium ethanolate; In ethanol; at 20 ℃; for 1h;

isoniazid; In ethanol; at 0 - 20 ℃;

DOI:10.1016/S0223-5234(99)00124-5

Reference yield: 65.0%

3-pyridinecarboxaldehyde (500-22-1) + Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide (261363-01-3) → Isonicotinic acid [2-(4-nitro-phenoxy)-1-{[1-pyridin-3-yl-meth-(E)-ylidene]-amino}-eth-(E)-ylidene]-hydrazide

Guidance literature:

With piperidine; In ethanol; for 6h; Heating;

DOI:10.1016/S0223-5234(99)00124-5

Reference yield: 62.0%

pyridine-4-carbaldehyde (872-85-5) + Isonicotinic acid [1-amino-2-(4-nitro-phenoxy)-eth-(E)-ylidene]-hydrazide (261363-01-3) → Isonicotinic acid [2-(4-nitro-phenoxy)-1-{[1-pyridin-4-yl-meth-(E)-ylidene]-amino}-eth-(E)-ylidene]-hydrazide

Guidance literature:

With piperidine; In ethanol; for 6h; Heating;

DOI:10.1016/S0223-5234(99)00124-5

upstream raw materials:

isoniazid

2-(4-nitrophenoxy)acetonitrile