1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one

Base Information

Chemical Name:1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one
CAS No.:191859-55-9
Molecular Formula:C₄₂H₅₀N₂O₅SSi₂
Molecular Weight:751.106
Hs Code.:

Synonyms:1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one

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Chemical Property of 1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one

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Technology Process of 1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one

There total 6 articles about 1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 191859-53-7
Acetic acid 2,2-bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl ester

: 191859-55-9
1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at -20 - 20 ℃; for 2h;
DOI:10.1016/S0960-894X(97)00250-3

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 191859-55-9
1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / imidazole / tetrahydrofuran / 0.67 h / Ambient temperature

2: mCPBA / CH₂Cl₂ / 0.5 h / 0 °C

3: 34 percent / NaOAc / 72 h / Heating

4: 49 percent / TMSOTf / 1,2-dichloro-ethane / 2 h / -20 - 20 °C

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; sodium acetate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(97)00250-3

Reference yield:

: 191859-49-1
(2-Hydroxymethyl-[1,3]oxathiolan-2-yl)-methanol

: 191859-55-9
1-[2,2-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3]oxathiolan-4-yl]-4-hydroxy-5-methyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / imidazole / tetrahydrofuran / 0.67 h / Ambient temperature

2: mCPBA / CH₂Cl₂ / 0.5 h / 0 °C

3: 34 percent / NaOAc / 72 h / Heating

4: 49 percent / TMSOTf / 1,2-dichloro-ethane / 2 h / -20 - 20 °C

With 1H-imidazole; trimethylsilyl trifluoromethanesulfonate; sodium acetate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(97)00250-3