N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide

Base Information

Chemical Name:N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide
CAS No.:1319744-13-2
Molecular Formula:C₃₀H₃₅F₃N₂OSi
Molecular Weight:524.701
Hs Code.:

Synonyms:N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide

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Technology Process of N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide

There total 2 articles about N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1319744-30-3
N-(quinolin-8-yl)-3-(4-(trifluoromethyl)phenyl)propanamide

: 111409-79-1
1-bromo-2-(triisopropylsilyl)acetylene

: 1319744-13-2
N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide

Guidance literature:: With silver(I) acetate; palladium diacetate; lithium chloride; In toluene; at 110 ℃; for 15h;
DOI:10.1021/ja206002m

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1319744-13-2
N-(8-quinolinyl)-3-(4-(trifluoromethyl)phenyl)-5-(triisopropylsilyl)-4-pentynamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate

2: silver(I) acetate; palladium diacetate; lithium chloride / toluene / 15 h / 110 °C

With N-Bromosuccinimide; silver(I) acetate; palladium diacetate; silver nitrate; lithium chloride; In toluene;
DOI:10.1021/ja206002m