tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate

Base Information

• Chemical Name: tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate
• CAS No.: 153538-14-8
• Molecular Formula: C₃₁H₃₆FN₃O₅
• Molecular Weight: 549.642
• Mol file: 153538-14-8.mol

Synonyms:tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate

Chemical Property of tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate

There total 3 articles about tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

[6-(bromomethyl)-2,7-dimethyl-4-oxoquinazolin-3(4H)-yl]methyl pivalate hydrobromide (838858-84-7) + tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate (140373-03-1) → tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate (153538-14-8)

Guidance literature:

[6-(bromomethyl)-2,7-dimethyl-4-oxoquinazolin-3(4H)-yl]methyl pivalate hydrobromide; With sodium hydrogencarbonate; In water; toluene; at 65 ℃; for 1.5h;

tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate; With 2,6-dimethylpyridine; In toluene; at 15 - 105 ℃; for 24h;

Reference yield: 69.0%

tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate (140373-03-1) + 6-(bromomethyl)-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>-2,7-dimethylquinazoline (140373-01-9) → tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate (153538-14-8)

Guidance literature:

With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 95 ℃; for 8h;

DOI:10.1021/jm00006a019

Reference yield:

pentafluorophenyl o-fluoro-p-[N-(2,7-dimethyl-4-oxo-3-(pivaloyloxyethyl)-3,4-dihydroquinazolin-6-ylmethyl)-N-(prop-2-ynyl)-amino]benzoate + tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate (140373-03-1) + 6-(bromomethyl)-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>-2,7-dimethylquinazoline (140373-01-9) → tert-butyl 4-[[(3-{[(2,2-dimethylpropanoyl)oxy]methyl}-2,7-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino]-2-fluorobenzoate (153538-14-8)

Guidance literature:

With potassium carbonate; In tert-butyl 2-fluoro-4-aminobenzoate;

upstream raw materials:

tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate

6-(bromomethyl)-3,4-dihydro-4-oxo-3-<(pivaloyloxy)methyl>-2,7-dimethylquinazoline

[6-(bromomethyl)-2,7-dimethyl-4-oxoquinazolin-3(4H)-yl]methyl pivalate hydrobromide