1H-2-Benzopyran-4,5-diol, 3,4-dihydro-8-methoxy-1,3-dimethyl-, (1R,3S,4S)- (9CI)

Base Information

Chemical Name:1H-2-Benzopyran-4,5-diol, 3,4-dihydro-8-methoxy-1,3-dimethyl-, (1R,3S,4S)- (9CI)
CAS No.:758695-39-5
Molecular Formula:C₁₂H₁₆O₄
Molecular Weight:224.257
Hs Code.:
Mol file:758695-39-5.mol

Synonyms:1H-2-Benzopyran-4,5-diol, 3,4-dihydro-8-methoxy-1,3-dimethyl-, (1R,3S,4S)- (9CI)

Suppliers and Price of 1H-2-Benzopyran-4,5-diol, 3,4-dihydro-8-methoxy-1,3-dimethyl-, (1R,3S,4S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 1H-2-Benzopyran-4,5-diol, 3,4-dihydro-8-methoxy-1,3-dimethyl-, (1R,3S,4S)- (9CI)

Chemical Property:

PSA：58.92000
LogP:1.91390

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-2-Benzopyran-4,5-diol, 3,4-dihydro-8-methoxy-1,3-dimethyl-, (1R,3S,4S)- (9CI)

There total 10 articles about 1H-2-Benzopyran-4,5-diol, 3,4-dihydro-8-methoxy-1,3-dimethyl-, (1R,3S,4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 714962-25-1
Toluene-4-sulfonic acid (1R,3S,4S)-4-hydroxy-8-methoxy-1,3-dimethyl-isochroman-5-yl ester

: 758695-39-5,569652-74-0
(1R,3S,4S)-3,4-Dihydro-4,5-dihydroxy-1,3-dimethyl-8-methoxy-2-benzopyran

Guidance literature:: With potassium hydroxide; water; In methanol; at 70 ℃; for 3h;
DOI:10.1016/j.tetlet.2004.06.065

Reference yield:

: 255824-19-2
(α'R,2S)-2-(5'-Benzyloxy-2'-methoxy-α'-methylbenzyloxy)propanal

: 758695-39-5,569652-74-0
(1R,3S,4S)-3,4-Dihydro-4,5-dihydroxy-1,3-dimethyl-8-methoxy-2-benzopyran

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 4 h

2: titanium tetraisopropoxide / CH₂Cl₂ / 5 h / ultrasonication bath

With titanium(IV) isopropylate; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate; 1: Hydrogenolysis / 2: Cyclization;
DOI:10.1039/a901457h

Reference yield:

: 255824-14-7
(α'R,2S)-2-(5'-Benzyloxy-2'-methoxy-α'-methylbenzyloxy)propan-1-ol

: 758695-39-5,569652-74-0
(1R,3S,4S)-3,4-Dihydro-4,5-dihydroxy-1,3-dimethyl-8-methoxy-2-benzopyran

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -70 - 20 °C

2: 92 percent / H₂ / 10 percent Pd/C / ethyl acetate / 4 h

3: titanium tetraisopropoxide / CH₂Cl₂ / 5 h / ultrasonication bath

With titanium(IV) isopropylate; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; 1: Oxidation / 2: Hydrogenolysis / 3: Cyclization;
DOI:10.1039/a901457h