Benzofuran, 2-cyclopropyl-

Base Information

• Chemical Name: Benzofuran, 2-cyclopropyl-
• CAS No.: 72474-33-0
• Molecular Formula: C11H10 O
• Molecular Weight: 158.2
• Mol file: 72474-33-0.mol

Synonyms:Benzofuran, 2-cyclopropyl-

Chemical Property of Benzofuran, 2-cyclopropyl-

Chemical Property:

• PSA: 13.14000
• LogP: 3.31020

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzofuran, 2-cyclopropyl-

There total 16 articles about Benzofuran, 2-cyclopropyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(2-cyclopropyl)ethynylphenol (870010-44-9) → cyclopropyl-2 benzofuranne (72474-33-0)

Guidance literature:

With platinum(II) chloride; In toluene; at 80 ℃; for 1h;

DOI:10.1021/ja055659p

Reference yield: 88.0%

Cyclopropylacetylene (6746-94-7) + 2-Iodophenol (533-58-4) → cyclopropyl-2 benzofuranne (72474-33-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 60 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2013.07.002

Reference yield: 61.0%

1-(cyclopropylethynyl)-(cyclopropylethynyl)anisole (1376626-97-9) → cyclopropyl-2 benzofuranne (72474-33-0)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 130 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmc.2013.07.002

upstream raw materials:

2-(2-cyclopropyl)ethynylphenol

1-(2-cyclopropylethynyl)-2-(methoxymethoxy)benzene

2-Iodophenol

1-iodo-2-methoxymethoxybenzene

Downstream raw materials:

(2-cyclopropylbenzofuran-3-yl)(phenyl)methanone

Refernces

• 1、 -. "A 2 - substituted benzofuran compound of the catalytic synthesis method". Paragraph 0019; 0020; 0021. . Retrieved 2019/05/22.
• 2、 Thévenin, Marion,Thoret, Sylviane,Grellier, Philippe,Dubois, Jo?lle. "Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth". supporting information. p. 4885 - 4892. Retrieved 2013/09/02.