cis-N-benzyl-2,5-dimethylpyrrolidine

Base Information

Chemical Name:cis-N-benzyl-2,5-dimethylpyrrolidine
CAS No.:4209-68-1
Molecular Formula:C₁₃H₁₉N
Molecular Weight:189.301
Hs Code.:

Synonyms:cis-N-benzyl-2,5-dimethylpyrrolidine

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Chemical Property of cis-N-benzyl-2,5-dimethylpyrrolidine

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Technology Process of cis-N-benzyl-2,5-dimethylpyrrolidine

There total 10 articles about cis-N-benzyl-2,5-dimethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2935-44-6
hexane-2,5-diol

: 100-46-9
benzylamine

: 4209-68-1
cis-N-benzyl-2,5-dimethylpyrrolidine

: 1-benzyl-2,5-dimethylpyrrolidine

Guidance literature:: With trimethylamine-N-oxide; [bis(hexamethylene)cyclopentadienone]iron tricarbonyl; In toluene; at 150 ℃; for 24h; Time; Overall yield = 66 percent; Overall yield = 62.5 mg; Inert atmosphere; Schlenk technique; Molecular sieve; Sealed tube;
DOI:10.1055/s-0039-1690101

Reference yield:

: 2935-44-6
hexane-2,5-diol

: 100-46-9
benzylamine

: 4209-68-1
cis-N-benzyl-2,5-dimethylpyrrolidine

: 1-benzyl-2,5-trans-dimethylpyrrolidine

Guidance literature:: With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium carbonate; In toluene; at 110 ℃; for 17h; Title compound not separated from byproducts;
DOI:10.1021/ol048619j

Reference yield:

: 625-84-3
2,5-Dimethylpyrrole

: 4209-68-1
cis-N-benzyl-2,5-dimethylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butoxide / tetrahydrofuran / 96 h / Heating

2: 72 percent / H₂ / 5percent Pt/C / methanol / 1.5 h / 760 Torr / Ambient temperature

3: 2N methanolic hydrochloric acid / 2.5 h / Heating

4: sodium carbonate / acetone / 2 h / Heating

With hydrogenchloride; potassium tert-butylate; hydrogen; sodium carbonate; platinum on activated charcoal; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jo00196a020