Technology Process of cis-N-benzyl-2,5-dimethylpyrrolidine
There total 10 articles about cis-N-benzyl-2,5-dimethylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylamine-N-oxide; [bis(hexamethylene)cyclopentadienone]iron tricarbonyl;
In
toluene;
at 150 ℃;
for 24h;
Time;
Overall yield = 66 percent; Overall yield = 62.5 mg;
Inert atmosphere;
Schlenk technique;
Molecular sieve;
Sealed tube;
DOI:10.1055/s-0039-1690101
- Guidance literature:
-
With
bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium carbonate;
In
toluene;
at 110 ℃;
for 17h;
Title compound not separated from byproducts;
DOI:10.1021/ol048619j
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium tert-butoxide / tetrahydrofuran / 96 h / Heating
2: 72 percent / H2 / 5percent Pt/C / methanol / 1.5 h / 760 Torr / Ambient temperature
3: 2N methanolic hydrochloric acid / 2.5 h / Heating
4: sodium carbonate / acetone / 2 h / Heating
With
hydrogenchloride; potassium tert-butylate; hydrogen; sodium carbonate;
platinum on activated charcoal;
In
tetrahydrofuran; methanol; acetone;
DOI:10.1021/jo00196a020
