N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide

Base Information

Chemical Name:N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide
CAS No.:80021-11-0
Molecular Formula:C₂₃H₂₁N₇O₃
Molecular Weight:443.465
Hs Code.:

Synonyms:N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide

There total 13 articles about N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20807-64-1
4-methyl-2-(4-nitrophenyl)pyridine

: 80021-11-0
N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: 30percent aq. H₂O₂ / acetic acid / 20 h / 80 °C

2: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

3: 5 M aq. HCl / 11 h / Heating

4: H₂, AcONa / 10percent Pd/C / dimethylformamide

5: SOCl₂ / 4 h / Heating

6: 75 percent / aq. NaHCO₃ / ethyl acetate / 0.75 h

7: K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

8: 5percent methanolic KOH / 1 h / Ambient temperature

9: dimethylformamide / 1 h / Ambient temperature

10: dimethylformamide / 2 h / 60 - 70 °C

With hydrogenchloride; potassium hydroxide; thionyl chloride; hydrogen; dihydrogen peroxide; sodium acetate; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfate; palladium on activated charcoal; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-65-4
4-methyl-2-(4-nitrophenyl)pyridine N-oxide

: 80021-11-0
N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Me₂SO₄ / 1.) 80-90 deg C, 2 h, 2.) dioxane, H₂O, RT, 30 min

2: 5 M aq. HCl / 11 h / Heating

3: H₂, AcONa / 10percent Pd/C / dimethylformamide

4: SOCl₂ / 4 h / Heating

5: 75 percent / aq. NaHCO₃ / ethyl acetate / 0.75 h

6: K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

7: 5percent methanolic KOH / 1 h / Ambient temperature

8: dimethylformamide / 1 h / Ambient temperature

9: dimethylformamide / 2 h / 60 - 70 °C

With hydrogenchloride; potassium hydroxide; thionyl chloride; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026

Reference yield:

: 80021-68-7
2-cyano-4-methyl-6-(4-nitrophenyl)pyridine

: 80021-11-0
N-(5-tetrazolyl)-4-methyl-6-(4-N-methyl-N-benzyloxycarbonylaminophenyl)-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 5 M aq. HCl / 11 h / Heating

2: H₂, AcONa / 10percent Pd/C / dimethylformamide

3: SOCl₂ / 4 h / Heating

4: 75 percent / aq. NaHCO₃ / ethyl acetate / 0.75 h

5: K₂CO₃ / dimethylformamide / 18 h / Ambient temperature

6: 5percent methanolic KOH / 1 h / Ambient temperature

7: dimethylformamide / 1 h / Ambient temperature

8: dimethylformamide / 2 h / 60 - 70 °C

With hydrogenchloride; potassium hydroxide; thionyl chloride; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a026