(-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol

Base Information

• Chemical Name: (-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol
• CAS No.: 1182843-49-7
• Molecular Formula: C₁₄H₁₂ClN₃O
• Molecular Weight: 273.722
• Mol file: 1182843-49-7.mol

Synonyms:(-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol

Chemical Property of (-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol

There total 4 articles about (-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) + (1R)-2-azido-1-(4-chlorophenyl)ethan-1-ol → (-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol (1182843-49-7)

Guidance literature:

With cesium fluoride; In acetonitrile; at 20 ℃;

DOI:10.5935/0103-5053.20130181

Reference yield:

4-chlorobenzoylmethyl bromide (536-38-9) → (-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol (1182843-49-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / acetone

2: sodium tetrahydroborate / methanol

3: Candida antarctica lipase / hexane / 168 h / 32 °C / Enzymatic reaction

4: cesium fluoride / acetonitrile / 20 °C

With Candida antarctica lipase; sodium tetrahydroborate; sodium azide; cesium fluoride; In methanol; hexane; acetone; acetonitrile;

DOI:10.5935/0103-5053.20130181

Reference yield:

rac-2-azido-1-(4-chlorophenyl)ethanol (861929-21-7) → (-)-(R)-2-(1H-benzo[d][1,2,3]triazol-1-yl)-1-(4-chlorophenyl)ethanol (1182843-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Candida antarctica lipase / hexane / 168 h / 32 °C / Enzymatic reaction

2: cesium fluoride / acetonitrile / 20 °C

With Candida antarctica lipase; cesium fluoride; In hexane; acetonitrile;

DOI:10.5935/0103-5053.20130181

upstream raw materials:

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

rac-2-azido-1-(4-chlorophenyl)ethanol

4-chlorobenzoylmethyl bromide

2-azido-4'-chloroacetophenone