N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1527508-11-7
Molecular Formula:C₂₂H₁₈Cl₂F₃N₅O₄
Molecular Weight:544.317
Hs Code.:

Synonyms:N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 4 articles about N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-5-chloro-3-methyl-N-propyl-benzamide

: C₁₁H₄Cl₂F₃N₃O₃

: 1527508-11-7
N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; Reflux;
DOI:10.1016/j.bmc.2013.11.038

Reference yield:

: 904733-74-0,197507-85-0
5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazole

: 1527508-11-7
N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide; water / 1 h / 20 - 60 °C

1.2: 125 °C

2.1: potassium dihydrogenphosphate; sodium chlorite / water; acetonitrile / 20 °C / Cooling

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

4.1: triethylamine / tetrahydrofuran / Reflux

With sodium chlorite; potassium dihydrogenphosphate; oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.11.038

Reference yield:

: 904733-75-1
C₁₄H₇ClF₃N₃O₃

: 1527508-11-7
N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(2-chloro-6-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium dihydrogenphosphate; sodium chlorite / water; acetonitrile / 20 °C / Cooling

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

3: triethylamine / tetrahydrofuran / Reflux

With sodium chlorite; potassium dihydrogenphosphate; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2013.11.038