3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene

Base Information

• Chemical Name: 3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene
• CAS No.: 220469-50-1
• Molecular Formula: C₂₇H₃₅NO₃S
• Molecular Weight: 453.646

Synonyms:3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene

Chemical Property of 3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene

There total 4 articles about 3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

N-n-butyl-N-methylamine (110-68-9) + 6-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-hexanoyl chloride → 3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene (220469-50-1)

Guidance literature:

In dichloromethane;

DOI:10.1002/(SICI)1521-4184(19989)331:9<283::AID-ARDP283>3.0.CO;2-N

Reference yield:

5-bromovaleroyl chloride (4509-90-4) → 3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene (220469-50-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 46 percent / AlCl₃ / 1,2-dichloro-ethane / 1 h / Ambient temperature

2: 91 percent / AlCl₃, LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

3: 1) Mg, I₂ / 1) Et₂O, THF, reflux, 1 h, 2) Et₂O, THF, 35 deg C, 10 h

4: PCl₅ / 0.5 h / 60 °C

5: 48 percent / CH₂Cl₂

With lithium aluminium tetrahydride; aluminium trichloride; phosphorus pentachloride; iodine; magnesium; In diethyl ether; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/(SICI)1521-4184(19989)331:9<283::AID-ARDP283>3.0.CO;2-N

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 3-[5-(n-butyl-methylcarbamoyl)pentyl]-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene (220469-50-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 46 percent / AlCl₃ / 1,2-dichloro-ethane / 1 h / Ambient temperature

2: 91 percent / AlCl₃, LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

3: 1) Mg, I₂ / 1) Et₂O, THF, reflux, 1 h, 2) Et₂O, THF, 35 deg C, 10 h

4: PCl₅ / 0.5 h / 60 °C

5: 48 percent / CH₂Cl₂

With lithium aluminium tetrahydride; aluminium trichloride; phosphorus pentachloride; iodine; magnesium; In diethyl ether; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/(SICI)1521-4184(19989)331:9<283::AID-ARDP283>3.0.CO;2-N

upstream raw materials:

N-n-butyl-N-methylamine

5-bromovaleroyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

6-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl]hexanoic acid

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