N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

Base Information

Chemical Name:N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide
CAS No.:195986-32-4
Molecular Formula:C₂₃H₂₀ClN₅
Molecular Weight:401.898
Hs Code.:

Synonyms:N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

Suppliers and Price of N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

There total 5 articles about N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 98557-54-1
N-(4-chlorophenyl)-N'-cyanothiourea

: 195983-72-3
7-phenyl-1,4-benzodiazepin

: 195986-32-4
N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 18h;
DOI:10.1021/jm990391w

Reference yield: 75.0%

: 195986-32-4
N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

Guidance literature:

Reference yield:

: 195986-74-4
2,3,4,5-Tetrahydro-7-bromo-1H-1,4-benzodiazepine-2,5-dione

: 195986-32-4
N-(4-chlorophenyl)-N'-cyano-1,2,3,5-tetrahydro-7-phenyl-4H-1,4-benzodiazepin-4-imidazmide

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / tetrakis(triphenylphosphine)palladium; aq. Na₂CO₃ / dimethylformamide; tetrahydrofuran / 48 h / 80 - 90 °C

2: LAH / tetrahydrofuran / 18 h / Heating

3: 75 percent / EDC / dimethylformamide / 18 h

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Substitution / 2: Reduction / 3: Condensation;
DOI:10.1021/jm990391w