2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Base Information

Chemical Name:2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate
CAS No.:1398111-34-6
Molecular Formula:C₂₈H₂₄ClFN₆O₃S*H₂O₄S
Molecular Weight:677.134
Hs Code.:

2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Synonyms:2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Suppliers and Price of 2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

There total 8 articles about 2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1125633-39-7
C₂₈H₂₄ClFN₆O₃S

: 1398111-34-6
2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Guidance literature:: With sulfuric acid; In n-heptane; ethyl acetate; at 50 ℃; for 0.5h;
DOI:10.1016/j.bmc.2012.07.032

Reference yield:

: 1125632-12-3
methyl 2-chloro-3-(1-cyano-1-methylethoxy)benzoate

: 1398111-34-6
2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / isopropyl alcohol / 2 h / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / 1 h / 20 °C

3: sulfuric acid / ethyl acetate; n-heptane / 0.5 h / 50 °C

With pyridine; sulfuric acid; water; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In n-heptane; ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.07.032

Reference yield:

: 535170-18-4
tert-butyl (5-amino-2-fluorophenyl)carbamate

: 1398111-34-6
2-chloro-3-(1-cyano-1-methylethoxy)-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide sulfate

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic anhydride / 0.5 h / 20 °C

1.2: 16 h / 10 - 20 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: dimethyl sulfoxide / 19 h / 60 °C

4.1: 10% Pd/C; hydrogen / tetrahydrofuran; ethanol / 22 h / 20 °C / 2280.15 Torr

5.1: bromine / acetic acid / 1.67 h / 10 - 20 °C

6.1: pyridine / 1 h / 0 - 20 °C

7.1: methoxybenzene; trifluoroacetic acid / 1 h / 0 °C

8.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / 1 h / 20 °C

9.1: sulfuric acid / ethyl acetate; n-heptane / 0.5 h / 50 °C

With pyridine; dimethylsulfide borane complex; sulfuric acid; 10% Pd/C; hydrogen; bromine; acetic anhydride; methoxybenzene; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; n-heptane; acetic acid; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmc.2012.07.032