ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate

Base Information

• Chemical Name: ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate
• CAS No.: 865805-05-6
• Molecular Formula: C₂₇H₃₀Br₂N₂O₂
• Molecular Weight: 574.355
• Mol file: 865805-05-6.mol

Synonyms:ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate

Chemical Property of ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate

There total 1 articles about ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (329214-79-1) + ethyl N-[(2,4,6-tribromophenyl)(4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate (763110-65-2) → ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate (865805-05-6)

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 100 ℃; for 48h;

DOI:10.1021/jo0504363

Reference yield: 100.0%

ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate (865805-05-6) → ethyl N-nitroso-N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate (865805-06-7)

Guidance literature:

With acetic anhydride; acetic acid; sodium nitrite; at 0 - 20 ℃;

DOI:10.1021/jo0504363

Reference yield:

ethyl N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate (865805-05-6) → [2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)ketone

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / sodium nitrite; acetic anhydride; acetic acid / 0 - 20 °C

2: 28 percent / t-BuOK / tetrahydrofuran / -20 °C

3: O₂ / benzene / Irradiation

With potassium tert-butylate; oxygen; acetic anhydride; acetic acid; sodium nitrite; In tetrahydrofuran; benzene;

DOI:10.1021/jo0504363

upstream raw materials:

3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

ethyl N-[(2,4,6-tribromophenyl)(4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate

Downstream raw materials:

ethyl N-nitroso-N-[[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)methyl]carbamate

[2,6-dibromo-4-(3-pyridyl)phenyl](4-tert-butyl-2,6-dimethylphenyl)diazomethane